USP22 antibody
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- Target See all USP22 Antibodies
- USP22 (Ubiquitin Specific Peptidase 22 (USP22))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This USP22 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein G column, followed by dialysis against PBS.
- Immunogen
- Purified His-tagged USP22 protein was used to produced this monoclonal antibody.
- Clone
- 1154CT13-1-3-1
- Isotype
- IgG1
- Top Product
- Discover our top product USP22 Primary Antibody
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- Application Notes
- WB: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Expiry Date
- 6 months
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A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing." in: Molecular cell, Vol. 29, Issue 1, pp. 92-101, (2008) (PubMed).
: "The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression." in: Molecular cell, Vol. 29, Issue 1, pp. 102-11, (2008) (PubMed).
: "The expression patterns of deubiquitinating enzymes, USP22 and Usp22." in: Gene expression patterns : GEP, Vol. 6, Issue 3, pp. 277-84, (2006) (PubMed).
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A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing." in: Molecular cell, Vol. 29, Issue 1, pp. 92-101, (2008) (PubMed).
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- Target
- USP22 (Ubiquitin Specific Peptidase 22 (USP22))
- Alternative Name
- USP22 (USP22 Products)
- Background
- Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
- Molecular Weight
- 59961
- NCBI Accession
- NP_056091
- UniProt
- Q9UPT9
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