CYP1A1 antibody (C-Term)

Catalog No. ABIN1882232

Product Details anti-CYP1A1 Antibody

Target: CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))

Binding Specificity: AA 377-405, C-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CYP1A1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This CYP1A1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 377-405 amino acids from the C-terminal region of human CYP1A1.

Clone: 655CT6-1-2

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CYP1A1 antibody (ABIN1882232)

Licznerska, Szaefer, Wierzchowski, Sobierajska, Baer-Dubowska: "Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation." in: Molecular and cellular biochemistry, Vol. 425, Issue 1-2, pp. 169-179, (2017) (PubMed).

Pande, Amos, Eng, Frazier: "Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis." in: Molecular carcinogenesis, Vol. 49, Issue 11, pp. 974-80, (2010) (PubMed).

Sabitha, Reddy, Jamil: "Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer." in: Cancer epidemiology, Vol. 34, Issue 5, pp. 587-92, (2010) (PubMed).

Kumar, Yadav, Singh, Goel, Ahmed, Gupta, Grover, Banerjee: "CYP 1A1 polymorphism and organochlorine pesticides levels in the etiology of prostate cancer." in: Chemosphere, Vol. 81, Issue 4, pp. 464-8, (2010) (PubMed).

Yamaguti, Lourenço, Silveira, Tone, Lopes, Lima: "Increased risk for acute lymphoblastic leukemia in children with cytochrome P450A1 (CYP1A1)- and NAD(P)H:quinone oxidoreductase 1 (NQO1)-inherited gene variants." in: Acta haematologica, Vol. 124, Issue 3, pp. 182-4, (2010) (PubMed).

Target Details for CYP1A1

Target: CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))

Alternative Name: CYP1A1 (CYP1A1 Products)

Background: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown, however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

Molecular Weight: 58165

NCBI Accession: NP_000490

UniProt: P04798

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha