ARL6 antibody (N-Term)

Catalog No. ABIN1882064

Product Details anti-ARL6 Antibody

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARL6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ARL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ARL6.

Clone: RB4921

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ARL6 antibody (ABIN1882064)

Wiens, Tong, Esmail, Oh, Gerdes, Wang, Tempel, Rattner, Katsanis, Park, Leroux: "Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling." in: The Journal of biological chemistry, Vol. 285, Issue 21, pp. 16218-30, (2010) (PubMed).

Pasqualato, Renault, Cherfils: "Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication." in: EMBO reports, Vol. 3, Issue 11, pp. 1035-41, (2002) (PubMed).

Ingley, Williams, Walker, Tsai, Colley, Sayer, Tilbrook, Sarna, Beaumont, Klinken: "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit." in: FEBS letters, Vol. 459, Issue 1, pp. 69-74, (1999) (PubMed).

Jacobs, Schilf, Fliegert, Koling, Weber, Schürmann, Joost: "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal." in: FEBS letters, Vol. 456, Issue 3, pp. 384-8, (1999) (PubMed).

Target Details for ARL6

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Alternative Name: ARL6 (ARL6 Products)

Background: ARL6 belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described.

Molecular Weight: 21097

NCBI Accession: NP_001265222, NP_115522, NP_816931

UniProt: Q9H0F7