SUMO1 antibody

Catalog No. ABIN1882054

Product Details anti-SUMO1 Antibody

Target: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SUMO1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified recombinant GST-SUMO1 protein was used as immunogen.

Clone: 66AT1320

Isotype: IgG1

Application Details

Application Notes: WB: 1:100~500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SUMO1 antibody (ABIN1882054)

Li, Perkins, Su, Ma, Colson, Horne, Chen: "Gold nanoparticles as a platform for creating a multivalent poly-SUMO chain inhibitor that also augments ionizing radiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 11, pp. 4092-7, (2012) (PubMed).

Truong, Su, Song, Chen: "Entropy-driven mechanism of an E3 ligase." in: Biochemistry, Vol. 50, Issue 25, pp. 5757-66, (2011) (PubMed).

Jia, Li, Meng, Shi: "Association between polymorphisms at small ubiquitin-like modifier 1 and nonsyndromic orofacial clefts in Western China." in: DNA and cell biology, Vol. 29, Issue 11, pp. 675-80, (2010) (PubMed).

Mostowska, Hozyasz, Wojcicki, Biedziak, Paradowska, Jagodzinski: "Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 7, pp. 538-45, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, (2010) (PubMed).

Song, Wang, Jozwiak, Hu, Swiderski, Chen: "Stability of thioester intermediates in ubiquitin-like modifications." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 12, pp. 2492-9, (2009) (PubMed).

Shanwell, Ringdén, Wiechel, Rumin, Akerblom: "A study of the effect of ABO incompatible plasma in platelet concentrates transfused to bone marrow transplant recipients." in: Vox sanguinis, Vol. 60, Issue 1, pp. 23-7, (1991) (PubMed).

Target Details for SUMO1

Target: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Alternative Name: SUMO1 (SUMO1 Products)

Background: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Molecular Weight: 11557

NCBI Accession: NP_001005781, NP_001005782, NP_003343

UniProt: P63165

Pathways: M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway