SF3B4 antibody (AA 158-187)

Catalog No. ABIN1881796

Product Details anti-SF3B4 Antibody

Target: SF3B4 (Splicing Factor 3b, Subunit 4, 49kDa (SF3B4))

Binding Specificity: AA 158-187

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SF3B4 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SF3B4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-187 amino acids from the Central region of human SF3B4.

Clone: RB40410

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SF3B4 antibody (ABIN1881796)

Gudbjartsson, Walters, Thorleifsson, Stefansson, Halldorsson, Zusmanovich, Sulem, Thorlacius, Gylfason, Steinberg, Helgadottir, Ingason, Steinthorsdottir, Olafsdottir, Olafsdottir, Jonsson et al.: "Many sequence variants affecting diversity of adult human height." in: Nature genetics, Vol. 40, Issue 5, pp. 609-15, (2008) (PubMed).

Watanabe, Shionyu, Kimura, Kimata, Watanabe: "Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation." in: The Journal of biological chemistry, Vol. 282, Issue 28, pp. 20728-38, (2007) (PubMed).

Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening." in: Proteomics, Vol. 7, Issue 11, pp. 1775-85, (2007) (PubMed).

Target Details for SF3B4

Target: SF3B4 (Splicing Factor 3b, Subunit 4, 49kDa (SF3B4))

Alternative Name: SF3B4 (SF3B4 Products)

Background: This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.

Molecular Weight: 44386

NCBI Accession: NP_005841

UniProt: Q15427