c-MET antibody

Catalog No. ABIN1881539

Product Details anti-c-MET Antibody

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ZNF593 antibody is generated from rabbits immunized with a His fusion protein from human MET.

Clone: RB17704

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-c-MET antibody (ABIN1881539)

Holgren, Dougherty, Edwin, Cerasi, Taylor, Fichera, Joseph, Bissonnette, Khare: "Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas." in: Oncogene, Vol. 29, Issue 38, pp. 5241-53, (2010) (PubMed).

Song, Li, Tretiakova, Salgia, Cagle, Husain: "Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung." in: Archives of pathology & laboratory medicine, Vol. 134, Issue 11, pp. 1702-5, (2010) (PubMed).

Thanseem, Nakamura, Miyachi, Toyota, Yamada, Tsujii, Tsuchiya, Anitha, Iwayama, Yamada, Hattori, Matsuzaki, Matsumoto, Iwata, Suzuki, Suda, Kawai, Sugihara, Takebayashi, Takei, Ichikawa, Sugiyama et al.: "Further evidence for the role of MET in autism susceptibility. ..." in: Neuroscience research, Vol. 68, Issue 2, pp. 137-41, (2010) (PubMed).

Sugiura, Kawaguchi, Soejima, Katsumata, Gono, Baba, Kawamoto, Murakawa, Yamanaka, Hara: "Increased HGF and c-Met in muscle tissues of polymyositis and dermatomyositis patients: beneficial roles of HGF in muscle regeneration." in: Clinical immunology (Orlando, Fla.), Vol. 136, Issue 3, pp. 387-99, (2010) (PubMed).

Tyner, Fletcher, Wang, Yang, Rutenberg-Schoenberg, Beadling, Mori, Heinrich, Deininger, Druker, Loriaux: "MET receptor sequence variants R970C and T992I lack transforming capacity." in: Cancer research, Vol. 70, Issue 15, pp. 6233-7, (2010) (PubMed).

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: MET (MET Products)

Synonyms: AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody

Background: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 155541

NCBI Accession: NP_000236, NP_001120972

UniProt: P08581

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor