BRAP antibody (N-Term)

Catalog No. ABIN1881119

Product Details anti-BRAP Antibody

Target: BRAP (BRCA1 Associated Protein (BRAP))

Binding Specificity: AA 66-95, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRAP antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-95 amino acids from the N-terminal region of human BRAP.

Clone: RB41572

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BRAP antibody (ABIN1881119)

Fulcher, Roth, Fatima, Alvisi, Jans: "The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 5, pp. 1454-66, (2010) (PubMed).

Kamatani, Matsuda, Okada, Kubo, Hosono, Daigo, Nakamura, Kamatani: "Genome-wide association study of hematological and biochemical traits in a Japanese population." in: Nature genetics, Vol. 42, Issue 3, pp. 210-5, (2010) (PubMed).

Hinohara, Ohtani, Nakajima, Sasaoka, Sawabe, Lee, Ban, Park, Izumi, Kimura: "Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease." in: Journal of human genetics, Vol. 54, Issue 11, pp. 642-6, (2009) (PubMed).

Ganesh, Zakai, van Rooij, Soranzo, Smith, Nalls, Chen, Kottgen, Glazer, Dehghan, Kuhnel, Aspelund, Yang, Tanaka, Jaffe, Bis, Verwoert, Teumer, Fox, Guralnik, Ehret, Rice, Felix, Rendon et al.: "Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium...." in: Nature genetics, Vol. 41, Issue 11, pp. 1191-8, (2009) (PubMed).

Cui, Kamatani, Takahashi, Usami, Hosono, Kawaguchi, Tsunoda, Kamatani, Kubo, Nakamura, Matsuda: "Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk." in: Gastroenterology, Vol. 137, Issue 5, pp. 1768-75, (2009) (PubMed).

Target Details for BRAP

Target: BRAP (BRCA1 Associated Protein (BRAP))

Alternative Name: BRAP (BRAP Products)

Background: The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm.

Molecular Weight: 67305

NCBI Accession: NP_006759

UniProt: Q7Z569