DAXX antibody
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- Target See all DAXX Antibodies
- DAXX (Death-Domain Associated Protein (DAXX))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This DAXX antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)
- Purification
- Purified by Protein G affinity chromatography
- Immunogen
- Purified recombinant fragment of human DAXX expressed in E. Coli.
- Isotype
- IgG1
- Top Product
- Discover our top product DAXX Primary Antibody
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anti-Death-Domain Associated Protein (DAXX) (AA 561-660) antibody
DAXX Reactivity: Human WB, ELISA, IF, PLA Host: Mouse Monoclonal 4C2 unconjugated
anti-Death-Domain Associated Protein (DAXX) (AA 558-740) antibodyDAXX Reactivity: Human WB, ICC Host: Mouse Monoclonal DAXX-01 unconjugated
anti-Death-Domain Associated Protein (DAXX) antibodyDAXX Reactivity: Human WB, ELISA, FACS, ICC Host: Mouse Monoclonal 7A11 unconjugated
anti-Death-Domain Associated Protein (DAXX) (AA 56-345) antibodyDAXX Reactivity: Human, Rat WB, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-Death-Domain Associated Protein (DAXX) (C-Term) antibodyDAXX Reactivity: Human, Mouse WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Death-Domain Associated Protein (DAXX) antibodyDAXX Reactivity: Human WB, IF, EIA Host: Mouse Monoclonal 7A11 unconjugated
anti-Death-Domain Associated Protein (DAXX) (AA 580-740) antibodyDAXX Reactivity: Human WB, ICC, IP Host: Mouse Monoclonal DAXX-03 unconjugated
anti-Death-Domain Associated Protein (DAXX) (pSer213) antibodyDAXX Reactivity: Human, Rat WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Death-Domain Associated Protein (DAXX) (pSer495) antibodyDAXX Reactivity: Human, Rat WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Death-Domain Associated Protein (DAXX) (pSer213) antibodyDAXX Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB6929 unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 50 % glycerol and 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
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- Target
- DAXX (Death-Domain Associated Protein (DAXX))
- Alternative Name
- DAXX (DAXX Products)
- Background
- Daxx is a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF beta R2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF beta R2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described.
- Molecular Weight
- 81 kDa
- Gene ID
- 1616
- UniProt
- Q9UER7
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
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