CCR8 antibody (Middle Region)

Catalog No. ABIN184212

Product Details anti-CCR8 Antibody

Target: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Binding Specificity: Middle Region

Reactivity: Human, Cow, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MATIPLLVFY QVASEDGVLQ CYSFYNQQTL KWKIFTNFKM NILGLLIPFT

Predicted Reactivity: Cow: 93%, Human: 100%, Rabbit: 81%

Characteristics: This is a rabbit polyclonal antibody against CCR8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCR8

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 355 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CCR8

Target: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Alternative Name: CCR8 (CCR8 Products)

Background: CCR8 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. Its gene is located at the chemokine receptor gene cluster region.
Alias Symbols: CY6, TER1, CCR-8, CKRL1, CDw198, CMKBR8, GPRCY6, CMKBRL2, CC-CKR-8
Protein Interaction Partner: TPST2, TPST1, CCR8, CCL17, CCL16, CCL4, CCL1,
Protein Size: 355

Molecular Weight: 41 kDa

Gene ID: 1237

NCBI Accession: NM_005201, NP_005192

UniProt: P51685