PRKRA antibody (Middle Region)

Catalog No. ABIN183963

Product Details anti-PRKRA Antibody

Target: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRKRA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: RLPEYTLSQE GGPAHKREYT TICRLESFME TGKGASKKQA KRNAAEKFLA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PRKRA. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PRKRA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 313 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PRKRA antibody (ABIN183963)

Yoshida, Okamura, Hoshino, Shono, Yoshioka, Hinode, Yoshida: "Interaction between PKR and PACT mediated by LPS-inducible NF-?B in human gingival cells." in: Journal of cellular biochemistry, Vol. 113, Issue 1, pp. 165-73, (2011) (PubMed).

Target Details for PRKRA

Target: PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))

Alternative Name: PRKRA (PRKRA Products)

Background: PRKRA contains 3 DRBM (double-stranded RNA-binding) domains. It appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor and activates EIF2AK2 in absence of double stranded RNA (dsRNA).
Alias Symbols: RAX, PACT, DYT16, HSD14
Protein Interaction Partner: ZMAT3, PRKRA, TARBP2, LYAR, STAU1, UBC, H1F0, EIF2AK2, CCDC124, C1orf35, DDX50, NOC3L, NOP16, STAU2, ZNF346, GTPBP4, DICER1, RBM34, EBNA1BP2, IFRD2, TCOF1, BMI1, SRPK3, POLR2G, MDC1, CAND1, UBE2I, SIRT7, ZFP28, KIAA1377, NKRF, SNX5, RABEPK, CEBPZ, SHC1, Z
Protein Size: 313

Molecular Weight: 34 kDa

Gene ID: 8575

NCBI Accession: NM_003690, NP_003681

UniProt: O75569

Pathways: Regulatory RNA Pathways