TFAP2C antibody (N-Term)

Catalog No. ABIN183887

Product Details anti-TFAP2C Antibody

Target: TFAP2C (Transcription Factor AP-2 gamma (Activating Enhancer Binding Protein 2 Gamma) (TFAP2C))

Binding Specificity: N-Term

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFAP2C antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SASLIPHISG LEGGSVSARR EVYRRSDLLL PHAHALEAGL AENLGLHEMA

Predicted Reactivity: Mouse: 100%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against TCFAP2C. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of mouse TCFAP2C

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Antigen size: 449 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TFAP2C antibody (ABIN183887)

Shim, Cho, Seo, Kim, Ryu, Yoo, Yang, Kim, Bahk, Park: "Proteomic analysis of time-dependent difference of protein expression profile changes during neuronal differentiation of mouse embryonic stem cells." in: Molecules and cells, Vol. 29, Issue 3, pp. 239-44, (2010) (PubMed).

Al-Batran, Rafiyan, Atmaca, Neumann, Karbach, Bender, Weidmann, Altmannsberger, Knuth, Jäger: "Intratumoral T-cell infiltrates and MHC class I expression in patients with stage IV melanoma." in: Cancer research, Vol. 65, Issue 9, pp. 3937-41, (2005) (PubMed).

Target Details for TFAP2C

Target: TFAP2C (Transcription Factor AP-2 gamma (Activating Enhancer Binding Protein 2 Gamma) (TFAP2C))

Alternative Name: TCFAP2C (TFAP2C Products)

Background: Tcfap2c is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. Tcfap2c binds to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.
Alias Symbols: Stra2, Ap-2.2, Tcfap2c, AA409384, AP2gamma
Protein Size: 449

Molecular Weight: 49 kDa

Gene ID: 21420

NCBI Accession: NM_009335, NP_033361

UniProt: Q61312

Pathways: Stem Cell Maintenance