NR2E3 antibody (N-Term)

Catalog No. ABIN183753

Product Details anti-NR2E3 Antibody

Target: NR2E3 (Nuclear Receptor Subfamily 2, Group E, Member 3 (NR2E3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2E3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: METRPTALMS STVAAAAPAA GAASRKESPG RWGLGEDPTG VSPSLQCRVC

Predicted Reactivity: Cow: 86%, Human: 100%, Mouse: 93%, Pig: 79%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against NR2E3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR2E3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 410 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-NR2E3 antibody (ABIN183753)

Hayashi, Gekka, Goto-Omoto, Takeuchi, Kubo, Kitahara: "Novel NR2E3 mutations (R104Q, R334G) associated with a mild form of enhanced S-cone syndrome demonstrate compound heterozygosity." in: Ophthalmology, Vol. 112, Issue 12, pp. 2115, (2005) (PubMed).

Target Details for NR2E3

Target: NR2E3 (Nuclear Receptor Subfamily 2, Group E, Member 3 (NR2E3))

Alternative Name: NR2E3 (NR2E3 Products)

Background: NR2E3 is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. NR2E3 is a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome.This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: PNR, RNR, rd7, ESCS, RP37
Protein Interaction Partner: BCL11A, SIN3A, DHX30, TBL3, MYBBP1A, NCOR1, HDAC3, RBL1, RBBP7, RBBP4, HDAC1, CDK9, VDR, DEDD2, RBFOX2, IRF9, ZNF232, SNAPC1, PPARG, HOXC13, NR3C1, ELAVL2, POLR3D, RARA, NR1D1, CRX, RXRB, RXRA,
Protein Size: 410

Molecular Weight: 45 kDa

Gene ID: 10002

NCBI Accession: NM_014249, NP_055064

UniProt: Q9Y5X4

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway