ACTN2 antibody (C-Term)
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- Target See all ACTN2 Antibodies
- ACTN2 (Actinin, alpha 2 (ACTN2))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ACTN2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- IQSYSIRISS SNPYSTVTMD ELRNKWDKVK QLVPVRDQSL QEELARQHAN
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 83%
- Characteristics
- This is a rabbit polyclonal antibody against ACTN2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide corresponding to a region of Mouse
- Top Product
- Discover our top product ACTN2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 894 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ACTN2 (Actinin, alpha 2 (ACTN2))
- Alternative Name
- ACTN2 (ACTN2 Products)
- Background
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The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.
Alias Symbols: 1110008F24Rik
Protein Interaction Partner: Grip1, Ar, Grin2b, Grin1, Ldb3, ADORA2A, Raver1, Myoz1, Myoz3, Myoz2,
Protein Size: 894 - Molecular Weight
- 98 kDa
- Gene ID
- 11472
- NCBI Accession
- NM_033268, NP_150371
- UniProt
- Q9JI91
- Pathways
- Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
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