YAF2 antibody (Middle Region)
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- Target See all YAF2 Antibodies
- YAF2 (YY1 Associated Factor 2 (YAF2))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This YAF2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- GDLTVIITDF KEKAKSAPAS SAAGDQHSQG SCSSDSTERG VSRSSSPRGE
- Predicted Reactivity
- Cow: 80%, Dog: 80%, Guinea Pig: 80%, Horse: 80%, Human: 80%, Mouse: 100%, Rat: 80%
- Characteristics
- This is a rabbit polyclonal antibody against YAF2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of mouse YAF2
- Top Product
- Discover our top product YAF2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 179 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- YAF2 (YY1 Associated Factor 2 (YAF2))
- Alternative Name
- YAF2 (YAF2 Products)
- Background
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Yaf2 binds to MYC and inhibits MYC-mediated transactivation. Yaf2 also binds to MYCN and enhances MYCN-dependent transcriptional activation. Yaf2 increases calpain 2-mediated proteolysis of YY1 in vitro. Yaf2 is a component of the E2F6.com-1 complex, a repressive complex that methylates Lys-9 of histone H3, suggesting that it is involved in chromatin-remodeling.
Alias Symbols: 2810021M11Rik
Protein Interaction Partner: Map3k1, Kdm2b, Rnf2,
Protein Size: 179 - Molecular Weight
- 20 kDa
- Gene ID
- 67057
- NCBI Accession
- NM_024189, NP_077151
- UniProt
- Q99LW6
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