CIITA antibody (C-Term)
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- Target See all CIITA Antibodies
- CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CIITA antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MALWESLQQQ GEAQLLQAAE EKFTIEPFKA KSPKDVEDLD RLVQTQRLRN
- Predicted Reactivity
- Dog: 100%, Human: 79%, Mouse: 100%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against C2TA. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of mouse C2TA
- Top Product
- Discover our top product CIITA Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1078 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))
- Alternative Name
- C2TA (CIITA Products)
- Background
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C2ta is essential for transcriptional activity of the HLA class II promoter, activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. C2ta may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter
Alias Symbols: C2ta, Gm9475, EG669998
Protein Interaction Partner: Rfxank, Ssbp4, Ssbp3, Gmeb1, Cited4, Tcf3, Nfe2, Hoxa2, Ewsr1,
Protein Size: 1078 - Molecular Weight
- 119 kDa
- Gene ID
- 12265
- NCBI Accession
- NM_007575, NP_031601
- UniProt
- Q3U2P0
- Pathways
- Cancer Immune Checkpoints
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