CLCNKB antibody (C-Term)

Catalog No. ABIN183111

Product Details anti-CLCNKB Antibody

Target: CLCNKB (Chloride Channel Kb (CLCNKB))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCNKB antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ILAAGCPTEP VTLKLSPETS LHEAHNLFEL LNLHSLFVTS RGRAVGCVSW

Predicted Reactivity: Cow: 100%, Dog: 85%, Guinea Pig: 77%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against CLCNKB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CLCNKB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 687 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CLCNKB

Target: CLCNKB (Chloride Channel Kb (CLCNKB))

Alternative Name: CLCNKB (CLCNKB Products)

Background: Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels. Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter Syndrome. CLCNKA and CLCNKB are closely related (94 % sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.
Alias Symbols: CLCKB, ClC-K2, ClC-Kb, hClC-Kb
Protein Interaction Partner: Dlg4,
Protein Size: 687

Molecular Weight: 76 kDa

Gene ID: 1188

NCBI Accession: NM_000085, NP_000076

UniProt: P51801