CREB3 antibody (C-Term)

Catalog No. ABIN182665

Product Details anti-CREB3 Antibody

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Binding Specificity: C-Term

Reactivity: Human, Rat, Cow, Dog, Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREB3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YSSDTRGSLP AEHGVLSRQL RALPSEDPYQ LELPALQSEV PKDSTHQWLD

Predicted Reactivity: Cow: 92%, Dog: 100%, Horse: 92%, Human: 100%, Pig: 100%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against CREB3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CREB3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 371 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CREB3

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Alternative Name: CREB3 (CREB3 Products)

Background: CREB3 is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.
Alias Symbols: LZIP, LUMAN
Protein Interaction Partner: COPS5, HCFC1, JUN, CREB3L1, CREB3L3, CREB3, NFE2L3, NFE2L2, DDIT3, CEBPG, ATF4, ATF3, TTLL5, RRAS2, OS9, RABAC1, SQLE, BCAT2, CLP1, UBC, HDAC3, MALL, NFIL3, APPBP2, STX8, BNIP2, CCR1, EMD,
Protein Size: 371

Molecular Weight: 41 kDa

Gene ID: 10488

NCBI Accession: NM_006368, NP_006359

UniProt: Q5TCV1

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded Protein Response