CD276 antibody (AA 1-242)

Catalog No. ABIN1820150

Product Details anti-CD276 Antibody

Target: CD276

Binding Specificity: AA 1-242

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Recognizes mouse CD276, otherwise known as B7-H3, a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines. CD276 has been implicated in the development of acute and chronic transplant rejection, and is reported to have therapeutic potential as a regulator of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy. In mice, CD276 has been linked with the development of pathogenic Th2 cells during the induction phase of allergic asthma. Studies have shown that clone MJ18 inhibits stimulated CD4+ T-cell proliferation.

Purification: Protein G purified

Immunogen: Mouse IgG2a Fc-CD276 (aa 1-242).

Type of Immunogen: Fusion protein

Clone: MJ18

Isotype: IgG1

Application Details

Application Notes: Approved: Flo (1:25 - 1:200)

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for CD276

Target: CD276

Alternative Name: CD276 / B7-H3 (CD276 Products)

Background: Name/Gene ID: CD276

Synonyms: CD276, 4Ig-B7-H3, B7 homolog 3, B7-H3, CD276 antigen, CD276 Molecule, Costimulatory molecule, B7H3, B7RP-2

Gene ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints