TNFSF4 antibody

Catalog No. ABIN6796394

Product Details anti-TNFSF4 Antibody

Target: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFSF4 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Recognizes rat CD252, otherwise known as OX40L or CD134L, a 22kD type II transmembrane glycoprotein and member of the TNF superfamily, expressed by antigen-presenting cells including activated dendritic cells and B cells, and also by vascular endothelium. The interaction of CD252 with its receptor OX40/CD134, acts as a co-stimulator of T cell activation, proliferation and both Th1 and Th2 cytokine production, and is also important in activated B cell proliferation and secretion of immunoglobulins (Igs). CD252/OX40 interaction has been implicated in HTLV-1 associated diseases including myelopathy and adult T cell leukaemia, and also with the autoimmune diseases rheumatoid arthritis and inflammatory bowel disease. Clone ATM-2 has been shown to block the co-stimulatory activity of CD252 on rat T cell proliferation.

Purification: Protein G purified

Immunogen: ACI-S1 rat T-cell lymphoma cell line.

Type of Immunogen: Cells

Clone: ATM-2

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Rat

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for TNFSF4

Target: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Alternative Name: TNFSF4 / OX40L (TNFSF4 Products)

Background: Name/Gene ID: TNFSF4
Family: TNF

Synonyms: TNFSF4, CD134 ligand, CD134L, CD252 antigen, Glycoprotein Gp34, OX-40L, OX40 ligand, TXGP1, OX40L, OX4OL, CD252, gp34, OX40 antigen ligand

Gene ID: 7292

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation, Cancer Immune Checkpoints