C6 antibody

Catalog No. ABIN181137

Product Details anti-C6 Antibody

Target: C6 (Complement Component 6 (C6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This C6 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes complement component 6 (C6). This antibody recognizes MAC.

Characteristics: Synonyms: Complement component C6, Complement 6

Purification: Affinity Chromatography on Protein A

Immunogen: Purified Human C6

Clone: 056B-214-2-4-2

Isotype: IgG1

Application Details

Application Notes: ELISA. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Borate buffered saline pH 8.2-8.4 containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for C6

Target: C6 (Complement Component 6 (C6))

Alternative Name: Complement C6 (C6 Products)

Synonyms: zgc:64073 antibody, MGC82168 antibody, c6 antibody, MGC89471 antibody, C6 antibody, AW111623 antibody, complement component 6 antibody, complement C6 antibody, complement component 6, gene 1 L homeolog antibody, complement component 6, gene 2 antibody, c6 antibody, C6 antibody, c6.1.L antibody, c6.2 antibody

Background: C6 is a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C terminus of the C5b alpha-chain, anchoring the molecule to the membrane and also binds complement component 7. This enables the formation of the C5b-7 precursor complex. C5b-7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection.

Gene ID: 729

UniProt: P13671