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p53 antibody

TP53 Reactivity: Human, Monkey WB, ELISA, IHC, FACS, IP Host: Mouse Monoclonal B-P3 unconjugated

Catalog No. ABIN1724545

Datasheet as PDF

Target See all p53 (TP53) Antibodies

p53 (TP53) (Tumor Protein P53 (TP53))
Reactivity
823

252

208

103

47

33

31

18

10

9

7

6

6

3

3

3

2

2

2

2

2

1

1

1
Human, Monkey
Host
623

217

6

2

1
Mouse
Compatible Secondaries
Clonality
559

289

1
Monoclonal
Conjugate
476

38

31

19

18

13

13

13

13

13

13

13

13

13

12

11

11

11

11

11

11

11

11

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
This p53 antibody is un-conjugated
Application
661

297

246

200

198

148

124

121

119

64

59

32

18

16

13

12

9

9

8

6

4

3

3

2

2

2

1

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificity

Reacts with wild type and mutant human p53, cross-react with p53 in other primates

Cross-Reactivity (Details)

The epitope is within residues 18-30 of human p53

Purification

Purified

Immunogen

Recombinant p53 protein

Clone

B-P3

Isotype

IgG2a

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anti-Tumor Protein P53 (TP53) (pSer392) antibody
TP53 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (N-Term) antibody
TP53 Reactivity: Human WB, IF, IHC (p), IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) antibody
KO Validated TP53 Reactivity: Human WB, IF, IHC (p), IP, ICC, ChIP Host: Rabbit Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 1-100) antibody
TP53 Reactivity: Human WB, IHC, IP Host: Rabbit Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 301-393) antibody
TP53 Reactivity: Human, Mouse, Rat, Goat WB, ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (acLys319) antibody
TP53 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (pSer20) antibody
TP53 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (pSer15) antibody
TP53 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 293-322) antibody
TP53 Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal RB7777 unconjugated

anti-Tumor Protein P53 (TP53) (pSer33) antibody
TP53 Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated

Application Notes

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB(1:100 - 1:1000) IP(1 - 2 μg per 100-500 μg of total protein) IF(1:50 - 1:500) IHC(1:50 - 1:500)

Restrictions

For Research Use only
Concentration

1 μg/μL

Buffer

PBS. Sterile-filtered through 0.22 μm.

Storage

4 °C/-20 °C

Storage Comment

Stable at +2 to 8°C for 12 months For longer storage, freeze aliquots

Expiry Date

12 months
Target

p53 (TP53) (Tumor Protein P53 (TP53))

Alternative Name

p53 (TP53 Products)

Background

Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Gene ID

7157

UniProt

P04637

Pathways

p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect