FRS2 antibody (pTyr436)

Catalog No. ABIN1532103

Product Details anti-FRS2 Antibody

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Binding Specificity: AA 402-451, pTyr436

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity:

FRS2 (Phospho-Tyr436) Antibody detects endogenous levels of FRS2 only when phosphorylated at Tyr436.

PhosphorylationH:Y436 M:Y436

Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436.

Isotype: IgG

Application Details

Application Notes: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:10000

Comment:

Unigene-Number: Hs.593446 (NCBI Gene Symbol: FRS2)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable at -20°C for at least 1 year.

Expiry Date: 12 months

References for anti-FRS2 antibody (ABIN1532103)

Sun, Zou, Yang, Morita, Gong, Shiba, Akagawa, Yuan: "Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway." in: Biochemical and biophysical research communications, Vol. 428, Issue 2, pp. 298-302, (2012) (PubMed).

Target Details for FRS2

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Alternative Name: FRS2 (FRS2 Products)

Background:

Synonyms: FGFR signalling adaptor, FGFR signalling adaptor SNT-1, SNT-1, SNT2, SUC1-associated neurotrophic factor target, Suc1-associated neurotrophic factor target

NCBI Gene Symbol: FRS2

Molecular Weight: 57 kDa

Gene ID: 10818

OMIM: 607743

UniProt: Q8WU20

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2