IL18R1 antibody (Extracellular Domain, N-Term)

Catalog No. ABIN1449294

Product Details anti-IL18R1 Antibody

Target: IL18R1 (Interleukin 18 Receptor 1 (IL18R1))

Binding Specificity: AA 1-329, Extracellular Domain, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL18R1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: This antibody detects IL-18R1.

Cross-Reactivity (Details): Species reactivity (tested):Human (KG-1). Does not react with Mouse transfected cells.

Purification: Protein A agarose

Immunogen: Human IL-18R1 extracellular domain corresponding to amino acids 1-329

Clone: 44G6

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for IL18R1

Target: IL18R1 (Interleukin 18 Receptor 1 (IL18R1))

Alternative Name: CD218a / IL18R1 (IL18R1 Products)

Synonyms: CD218a antibody, CDw218a antibody, IL-1Rrp antibody, IL18RA antibody, IL1RRP antibody, IL-1R9 antibody, IL1R9 antibody, IL1RAPL-2 antibody, TIGIRR-1 antibody, Il18ralpha antibody, Il1rrp antibody, IL-18Ra antibody, IL18R1 antibody, interleukin 18 receptor 1 antibody, interleukin 1 receptor accessory protein like 2 antibody, IL18R1 antibody, IL1RAPL2 antibody, Il18r1 antibody

Background: IL-18 is a proinflammatory cytokine that can synergize with IL-12 to increase IFN-γ production, NK cell cytotoxity, and Th1 responses, and involves in chronic inflammation, autoimmune diseases, and a variety of cancers. The receptor of IL-18 is a complex of two polypeptide chains, IL-18 receptor 1 (IL-18R1/IL-18Ra/CD218a) and IL-18 receptor accessory protein (IL-18Rap/IL-18 receptor ß/CD218b). Both chain are essential for IL-18 signal transduction. IL-18R1 is a glycosylated membrane protein of 60-100 kDa expressed on variety of cells containing Th1 cells, NK cells, renal epithelial cells and prostate cancer cells. It is a member of IL-1 receptor family and works as ligand binding chain of IL-18R complex.Synonyms: CD218 antigen-like family member A, CDw218a, IL-18 receptor 1, IL-1Rrp, IL1 receptor-related protein, IL1RRP, Interleukin-18 receptor 1

Gene ID: 8809

NCBI Accession: NP_003846

UniProt: Q13478