ICAM1 antibody (FITC)
-
- Target See all ICAM1 Antibodies
- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This ICAM1 antibody is conjugated to FITC
-
Application
- Flow Cytometry (FACS)
- Purification
- Protein A agarose
- Immunogen
- Human myeloma cell line (RPMI8226)
- Clone
- WK1
- Isotype
- IgG1
- Top Product
- Discover our top product ICAM1 Primary Antibody
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 1 % BSA and 0.09 % NaN3.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8 °C.
-
- Target
- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
- Alternative Name
- CD54 / ICAM1 (ICAM1 Products)
- Target Type
- Viral Protein
- Background
- Intercellular adhesion molecules (ICAMs) are type I transmem brane glycoproteins, which contain 2-9 immunoglobulin-like C2-type domains, and bind to lymphocyte function- associated antigen-1 (LFA-1, also known as a L/ ß 2 or CD11a/CD18). ICAM-1 (CD54) binds to not only LFA-1 but also CD11b/CD18 (Mac-1) and CD11c/CD18. ICAM-1 is also the major receptor for human rhinovirus. ICAM-1 and LFA-1 are involved in the formation of the adhesion ring junction at the immunologic synapse between T cells and antigen presenting cells. ICAM-1 is expressed at low levels on diverse cell types, and is readily induced by activation with proinflammatory cytokines such as IL-1, TNF, IFN- γ , and GM-CSF. ICAM-1 plays a role in both adhesion and extravasation of leukocytes to endothelium during inflammation. Soluble forms of ICAM-1 (sICAM-1) have been detected in a variety of body fluids and correlated with the intensity of the clinical condition of inflammatory and immune disorders. Several studies have provided evidence that sICAM-1 can bind to cell surface ß 2 integrins (CD18), causing reduced adherence of leukocytes to endothelial cells and the accompanying intracellular signaling responses.Synonyms: ICAM-1, Intercellular adhesion molecule 1, Major Group Rhinovirus Receptor
- Gene ID
- 9606
- UniProt
- P05362
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
-