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- Target See all p53 (TP53) Antibodies
- p53 (TP53) (Tumor Protein P53 (TP53))
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Binding Specificity
- pSer315
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Reactivity
- Human
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This p53 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- This antibody reacts with the human phosphorylated p53 (Ser315).
- Clone
- #18
- Isotype
- IgG2b
- Top Product
- Discover our top product TP53 Primary Antibody
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anti-Tumor Protein P53 (TP53) (pSer392) antibody
TP53 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (N-Term) antibodyTP53 Reactivity: Human WB, IF, IHC (p), IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) antibodyKO Validated TP53 Reactivity: Human WB, IF, IHC (p), IP, ICC, ChIP Host: Rabbit Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 1-100) antibodyTP53 Reactivity: Human WB, IHC, IP Host: Rabbit Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 301-393) antibodyTP53 Reactivity: Human, Mouse, Rat, Goat WB, ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (acLys319) antibodyTP53 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (pSer20) antibodyTP53 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (pSer15) antibodyTP53 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 293-322) antibodyTP53 Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal RB7777 unconjugated
anti-Tumor Protein P53 (TP53) (pSer33) antibodyTP53 Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
- Preservative
- Without preservative
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Upon receipt, store (in aliqouts) at -20 °C.
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- Target
- p53 (TP53) (Tumor Protein P53 (TP53))
- Alternative Name
- p53 (TP53) (TP53 Products)
- Background
- P53 mutants are found in more than half of human cancers and ar e considered as the most important human cancer related gene. p53 is detected at 53 kDa position by electrophoresis and is composed of 393 amino acids. In the unstressed normal cells the p53 level is low and it is inactive. However, with stress, especially with DNA damage, it is activated to promote arrest of cell cycle and repair of DNA damage, or induction of apoptosis. The functions of p53 are regulated by the phosphorylation of serine and threonine, and the acetylation of lysine at various sites in the molecule. Ser315 is phosphorylated by aurora kinase and cyclin-dependent kinases when cells are subjected to stress such as DNA damage and microtubule disruption by nocodazole Ref. 1-3 . However the effect of the phosphorylation on the function of p53 is largely unknown.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
- Gene ID
- 7157
- NCBI Accession
- NP_000537
- UniProt
- P04637
- Pathways
- p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
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