CD226 antibody (FITC)

Catalog No. ABIN1449203

Product Details anti-CD226 Antibody (FITC)

Target: CD226

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This CD226 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: This antibody reacts with human CD226/DNAM-1.

Purification: Protein G agarose

Immunogen: Recombinant human CD226/DNAM-1

Clone: TX25

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS, 0.09 % NaN3, 1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8 °C.

Target Details for CD226

Target: CD226

Alternative Name: CD226 / DNAM1 (CD226 Products)

Background: CD226/DNAM-1 (DNAX accessory molecule-1) is a 65 kDa type I transmembrane glycoprotein expressed on the majority of T cells, NK cells, monocytes, and a subset of B-cells. A soluble form (50 kDa) of CD226 is present in normal serum and the supernatant of cultured activated T cells. Ligand binding to CD226 results in phosphorylation of Ser329 and Tyr322, suggesting a role in signal transduction. CD226 acts as an adhesion molecule involved in the binding of certain tumor cells to CTL and NK cells and mediates their cytotoxicity. CD226 also stimulates TNF-α and IFN-γ secretion by alloantigen-specific T cells.Synonyms: DNAM-1, DNAX accessory molecule 1

Gene ID: 10666

NCBI Accession: NP_006557

UniProt: Q15762

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints