RAN antibody

Catalog No. ABIN1449197

Product Details anti-RAN Antibody

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Reactivity: Human, Mouse, Rat, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAN antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificity: This antibody reacts with Ran. ARAN1 inhibits the basic type NLS-dependent nuclear protein import. ARAN1 recognizes an epitope located the residues between 207 and 216 of human Ran.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat, Hamster

Purification: Protein A agarose

Immunogen: Recombinant human Ran

Clone: ARAN1

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for RAN

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Alternative Name: RAN (RAN Products)

Background: The Ran GTPase has important roles in nucleocytoplasmic transport, cell cycle progression, nuclear organization and nuclear envelope (NE) assembly. The small GTPase Ran is essential for spindle assembly. Ran is proposed to act through its nuclear import receptors importin and/or importin to control the sequestration of proteins necessary for spindle assembly. Ran, is required for coordinating the onset of mitosis with S-phase completion in mammalian cells. Other defects in the Ran-GTPase network also result in disruption of cell-cycle processes such as DNA replication, exit from mitosis and, at least in budding yeast, accurate chromosome segregation.Synonyms: ARA24, Androgen receptor-associated protein 24, GTP-binding nuclear protein Ran, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein

Molecular Weight: 25 kDa

Gene ID: 5901

NCBI Accession: NP_006316

UniProt: P62826

Pathways: Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus