ES1 Protein Homolog (AA 1-281), (full length), (N-Term) antibody
Reactivity: Rat
IF, IHC (p), IP, WB
Host: Rat
Monoclonal
NM1
unconjugated
-
- Target
- ES1 Protein Homolog
- Binding Specificity
- AA 1-281, full length, N-Term
- Reactivity
- Rat
- Host
- Rat
- Clonality
- Monoclonal
- Application
- Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
- Specificity
- This antibody reacts with rat HES1.
- Purification
- Protein G agarose
- Immunogen
- Full-length rat HES1 (1-281 aa)
- Clone
- NM1
- Isotype
- IgG2a
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
- Preservative
- Without preservative
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Target
- ES1 Protein Homolog
- Background
- Two transcription factors with a helix-loop-helix motif, human achaete-scute homologue-1 (hASH1) and hairy/enhancer of split homologue-1 (HES1), are essential for proper neuronal development. hASH1 is constitutively expressed in the most virulent human lung cancer, small cell lung cancer (SCLC), which exhibits neuroendocrine (NE) features. Moreover, hASH1 is essential for development of normal pulmonary NE cells that resemble SCLC. HES1 acts to transcriptionally repress hASH1 expression. The repressive effect of HES1 is mediated by binding of the protein to a class C site in the hASH1 promoter. HES1 also plays a role in mid- and hindbrain development, and in Notch signaling in thymocytes.Synonyms: C21orf33, HES1, KNPI, Protein GT335, Protein KNP-I
- Gene ID
- 294326
- NCBI Accession
- NP_001004225
- UniProt
- P56571
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