PD-L1 antibody

Catalog No. ABIN1449170

Product Details anti-PD-L1 Antibody

Target: PD-L1 (CD274 (PD-L1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PD-L1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: This antibody reacts with human PD-1.

Purification: Protein-A Sepharose

Immunogen: Human PD-1-Fc fusion protein

Clone: J110

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PD-L1

Target: PD-L1 (CD274 (PD-L1))

Alternative Name: CD274 / PDL1 (PD-L1 Products)

Background: Human PD-1 (programmed death-1) is a 55KDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in peripheral tolerance and autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells.Synonyms: B7 homolog 1, B7H1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, Programmed death ligand 1

Gene ID: 29126

NCBI Accession: NP_054862

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints