CGA antibody

Catalog No. ABIN120023

Product Details anti-CGA Antibody

Target: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CGA antibody is un-conjugated

Application: Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Radioimmunoassay (RIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: A high affinity antibody recognising the alpha 4 epitope of the alpha-subunit of Human Chorionic Gonadotrophin (hCG), hLH, hFSH, hTSH and free alpha-subunit. The recognised epitope comprises amino-acids alpha 15 to alpha 22 of the human sequence. Can be used in combination with INN-hCG-2, 22, 24, 32, 72 and INN-hFSH-6 and 60. This antibody will not cross-react with glycoprotein hormones of various animal species.

Purification: Ion exchange chromatography

Immunogen: Human Follicle Stimulating Hormone (FSH). Spleen cells from immunised mice were fused with cells of the X63-Ag8.653 myeloma cell line.

Clone: INN-hFSH 132

Isotype: IgG1

Application Details

Application Notes: Immunohistochemistry on paraffin sections. ELISA. Immunoprecipitation. Radioimmunoassay.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CGA

Target: CGA (Glycoprotein Hormones, alpha Polypeptide (CGA))

Alternative Name: Glycoprotein Hormones alpha Chain (CGA Products)

Background: The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.Synonyms: Anterior pituitary glycoprotein hormones common subunit alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, FSH-alpha, Follicle-stimulating hormone alpha chain, Follitropin alpha chain, LH alpha, LSH-alpha, Luteinizing hormone alpha chain, Lutropin alpha chain, TSH-alpha, Thyroid-stimulating hormone alpha chain, Thyrotropin alpha chain, hCG-alpha

Gene ID: 1081

NCBI Accession: NP_000726

UniProt: P01215

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport, Peptide Hormone Metabolism