DAXX antibody (C-Term)

Catalog No. ABIN119584

Product Details anti-DAXX Antibody

Target: DAXX (Death-Domain Associated Protein (DAXX))

Binding Specificity: AA 558-740, C-Term

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This DAXX antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: The antibody reacts with Daxx, a death domain containing protein mainly expressed in fetal and adult tissue.

Purification: Affinity Chromatography on Protein-A.

Immunogen: Recombinant C-terminal part (aa 558-740) of Human Daxx

Clone: DAXX-01

Isotype: IgG1

Application Details

Application Notes: Western Blot. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.4 with 15 mM Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Alternative Name: DAXX (DAXX Products)

Background: Daxx is an apoptosis-modulating death-domain associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).Synonyms: BING2, DAP6, Death domain-associated protein 6, EAP1, ETS1-associated protein 1, Fas death domain-associated protein

Gene ID: 1616

NCBI Accession: NP_001135441

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway