TSH receptor antibody
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- Target See all TSH receptor (TSHR) Antibodies
- TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TSH receptor antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)
- Specificity
- 2C11 recognises both native and denatured TSH receptor (binding to an epitope at the carboxy terminus between amino acids 354 and 359). It does inhibit binding of TSH. No cross reactivity has been observed with related LH and FSH receptors. This antibody recognises the mutant TSH receptor known as I167N as well as the wild type molecule.
- Purification
- Affinity chromatography on Protein G
- Immunogen
- Recombinant Human TSH receptor. Spleen cells from immunised BALB/c mice were fused with cells of the NS1/Ag4.1 mouse myeloma cell line.
- Clone
- 2C11
- Isotype
- IgG1
- Top Product
- Discover our top product TSHR Primary Antibody
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anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 21-253) antibody
TSHR Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 501-600) antibodyTSHR Reactivity: Human, Mouse, Rat WB, ELISA, FACS, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 201-300) antibodyTSHR Reactivity: Human, Mouse ELISA, FACS Host: Rabbit Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 648-740) antibodyTSHR Reactivity: Human, Mouse ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 28-245) antibodyTSHR Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (Internal Region) antibodyTSHR Reactivity: Human, Mouse WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (C-Term) antibodyTSHR Reactivity: Human, Monkey IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (N-Term) antibodyTSHR Reactivity: Human, Monkey IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) antibodyTSHR Reactivity: Human IHC, StM Host: Mouse Monoclonal TSHRB-1405 unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) antibodyTSHR Reactivity: Human ELISA, IHC, StM, Coat Host: Mouse Monoclonal TSHRA-1402 unconjugated
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- Application Notes
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Flow Cytometry. ELISA. Immunoprecipitation: 5-10 μg/mL. Western Blot: 5-10 μg/mL. Functional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
- Alternative Name
- Thyrotropin Receptor / TSHR (TSHR Products)
- Background
- The thyroid stimulating hormone (TSH) receptor (otherwise known as the thyrotropin receptor) is an important molecule in controlling the growth and function of the normal thyroid.Synonyms: LGR3, TSH-R, TSH-receptor, Thyroid-stimulating hormone receptor
- Gene ID
- 7253
- NCBI Accession
- NP_000360
- UniProt
- P16473
- Pathways
- Thyroid Hormone Synthesis
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