PLP1 antibody (C-Term)

Catalog No. ABIN119026

Product Details anti-PLP1 Antibody

Target: PLP1 (Proteolipid Protein 1 (PLP1))

Binding Specificity: C-Term

Reactivity: Human, Cow, Mammalian

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLP1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody recognizes Myelin Proteolipid protein (PLP) in many Mammalian species. This antibody also recognizes DM20.

Cross-Reactivity (Details): Species reactivity (tested):Bovine.

Purification: Affinity Chromatography on Protein A from Tissue Culture Supernatant

Immunogen: Synthetic peptide CGRGTKF corresponding to C-terminal region of Myelin Proteolipid Protein. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.

Clone: Plpc1

Isotype: IgG2a

Application Details

Application Notes: Western blot. Immunohistochemistry on Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PLP1

Target: PLP1 (Proteolipid Protein 1 (PLP1))

Alternative Name: PLP1 (PLP1 Products)

Background: Myelin proteins are associated with the central nervous system (CNS) and play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. The proteolipid protein (PLP) and its splice variant DM20 are the predominant myelin proteins in the CNS. PLP is also one of the most extensively studied myelin proteins because of the prevelance of PLP mutations amongst humans and animals. Such mutations can lead to abnormal myelin formation resulting in conditions such as X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease.Synonyms: Lipophilin, Myelin proteolipid protein, PLP

Gene ID: 281410

NCBI Accession: NP_776574

UniProt: P04116