HLA B7 antibody

Catalog No. ABIN118934

Product Details anti-HLA B7 Antibody

Target: HLA B7 (HLA Class I B7 Alpha (HLA B7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HLA B7 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: This antibody recognises the HLA-B7 antigen and does not cross-react with HLA-B27 or other related antigens. It can be used to distinguish true HLA-B27 positives from false HLA-B27 positives (i.e. HLA-B7 positive) in the investigation of diseases such as ankylosing spondylitis and anterior uveitis.

Purification: Affinity Chromatography on Protein A.

Immunogen: Papain solubilized HLA-B7 antigen.

Clone: BB7-1

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry: 1/50, Use 10 μL of the suggested working dilution to label 1 x 10^6 cells or 100 μL whole blood.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HLA B7

Target: HLA B7 (HLA Class I B7 Alpha (HLA B7))

Abstract: HLA B7 Products

Synonyms: AS antibody, HLAB antibody, SPDA1 antibody, major histocompatibility complex, class I, B antibody, HLA-B antibody

Background: HLA B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa. Hundreds of HLA B alleles have been described. Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). This antibody can be used for HLA typing.Synonyms: B-7 alpha chain, HLA class I histocompatibility antigen, HLAB, MHC class I antigen B7

Gene ID: 3106

NCBI Accession: NP_005505

UniProt: P01889

Pathways: Human Leukocyte Antigen (HLA) in Adaptive Immune Response