HLA-ABC antibody (PE)

Catalog No. ABIN118901

Product Details anti-HLA-ABC Antibody (PE)

Target: HLA-ABC

Reactivity: Human, Cow, Cat, Monkey, Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This HLA-ABC antibody is conjugated to PE

Application: Flow Cytometry (FACS)

No Cross-Reactivity: Goat, Dog (Canine), Guinea Pig, Rabbit, Mouse (Murine), Chicken, Amphibian

Cross-Reactivity (Details): Species reactivity (tested):Human, Cynomolgus monkey, Rhesus monkey, Chimpanzee, Macaque, Bovine, Baboon, Gorilla, Shrew.

Purification: Affinity chromatography on Protein G

Immunogen: Membrane of human tonsil cells. Spleen cells from immunised BALB/c mice were fused with cells of the NS1/1 - Ag4.1 mouse myeloma cell line.

Clone: W6-32

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 1 mL distilled water

Buffer: PBS, 0.09 % Sodium Azide, 1 % BSA, 5 % Sucrose

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Prior to and following reconstitution store the antibody at -20 °C.

References for anti-HLA-ABC antibody (PE) (ABIN118901)

Anders, Mollenhauer, Beberhold, Kinne, Venbrocks: "Gelatin-based haemostyptic Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix?: an experimental study with bovine chondrocytes." in: The Journal of bone and joint surgery. British volume, Vol. 91, Issue 3, pp. 409-16, (2009) (PubMed).

Stern, Goldman, Hatasaka, Mackenzie, Surrey, Racowsky,: "Optimizing the number of cleavage stage embryos to transfer on day 3 in women 38 years of age and older: a Society for Assisted Reproductive Technology database study." in: Fertility and sterility, (2008) (PubMed).

Mayr, Bund, Schlee, Moosmann, Kofler, Hallek, Wendtner: "Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes." in: Blood, Vol. 105, Issue 4, pp. 1566-73, (2005) (PubMed).

Mayr, Kofler, Büning, Bund, Hallek, Wendtner: "Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells." in: Blood, Vol. 106, Issue 9, pp. 3223-6, (2005) (PubMed).

Lauerová, Kovarik, Bártek, Rejthar, Vojt?sek: "Novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule." in: Hybridoma, Vol. 7, Issue 5, pp. 495-504, (1989) (PubMed).

Target Details for HLA-ABC

Target: HLA-ABC

Alternative Name: HLA Class I ABC (HLA-ABC Products)

Synonyms: HLAA antibody, major histocompatibility complex, class I, A antibody, HLA-A antibody

Background: The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. These proteins are found on the surface of almost all nucleated somatic cells.Synonyms: HLA Class 2 ABC, Human Leukocyte antigen class I ABC, MHC class I ABC, Major Histocompatibility complex class I

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints