IL10RA
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Restrictions
For Research Use only
Format
Liquid
Concentration
1.0 mg/mL
Buffer
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Preservative
Azide free
Storage
4 °C
Storage Comment
Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Liu, de Waal Malefyt, Briere, Parham, Bridon, Banchereau, Moore, Xu: "The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 2, pp. 604-13, (1997) (PubMed).
Carson, Lindemann, Baiocchi, Linett, Tan, Chou, Narula, Caligiuri: "The functional characterization of interleukin-10 receptor expression on human natural killer cells." in: Blood, Vol. 85, Issue 12, pp. 3577-85, (1995) (PubMed).
Reacts with 90-110 kDa protein expressed on T cells, B cells, NK cells, and monocyte/macrophages. It belongs to the class II cytokine receptor family which includes IFNgammaR (CDw119), IFNalpha/betaR (CD118) and tissue factor (CD142). IL-10R has been found to play a role in signal transduction by activating specific STAT proteins (STAT3 and STAT1) and inducing gene transcription. Other reports indicate that IL-10 protein binding to NK cells appears to be stimulatory, in contrast to its binding to T cells and monocytes/macrophages. Clone 3F9 is specific for human IL-10R and its binding to the receptor can be blocked by recombinant human IL-10 (rhIL-10). Synonyms: IL-10 receptor