FCGR1A antibody

Catalog No. ABIN1176933

Product Details anti-FCGR1A Antibody

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FCGR1A antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterility: 0.2 μm filtered

Endotoxin Level: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogen: Human rheumatoid synovial fluid cells and fibronectin-purified monocytes

Clone: 10-1

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

References for anti-FCGR1A antibody (ABIN1176933)

van Vugt, Heijnen, Capel, Park, Ra, Saito, Verbeek, van de Winkel: "FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo." in: Blood, Vol. 87, Issue 9, pp. 3593-9, (1996) (PubMed).

Dougherty, Selvendran, Murdoch, Palmer, Hogg: "The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1." in: European journal of immunology, Vol. 17, Issue 10, pp. 1453-9, (1987) (PubMed).

Target Details for FCGR1A

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Alternative Name: CD64 (FCGR1A Products)

Background: The 10.1 monoclonal antibody specifically binds to CD64, a 75 kDa type I transmembrane glycoprotein that is a high affinity receptor for human IgG (FcgammaRI), especially the IgG1 and IgG3 subclasses. CD64 is expressed on monocytes, macrophages, dendritic cells, granulocytes activated with interferon-gamma and early myeloid lineage cells. CD64 associates with a signaling FcRgamma homodimer to form the functional high affinity FcgammaRI complex. CD64 functions in both innate and adaptive immune responses and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release and superoxide generation.
Synonyms: FCGR1, FcRI, Fc-gamma RI, IgG Fc Receptor I, High affinity IgG FcR1

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process