CGRP antibody (AA 23-37)

Catalog No. ABIN112616

Product Details anti-CGRP Antibody

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Binding Specificity: AA 23-37

Reactivity: Rat, Mouse, Reptile

Host: Goat

Clonality: Polyclonal

Conjugate: This CGRP antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: Recognizes Calcitonin gene-related peptide, also known as CGRP, a neuropeptide that acts as a vasodilator and may play a role in migraine. This antibody is reactive with both whole molecule (1-37) and the C-terminal (23-37). Specifically visualises CGRP in brain cells.

Purification: Affinity Chromatography on Protein G

Immunogen: Synthetic Rat Tyr-CGRP (23-37) conjugated to gamma globulin

Isotype: IgG

Application Details

Application Notes: ELISA (1/500-1/2500). Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 5.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CGRP

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Alternative Name: CGRP / CALCA (CALCA Products)

Background: CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat, it can modulate acetylcholine receptor function at the neuromuscular junction, it has been demonstrated to block tolerance to morphine, and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.Synonyms: Alpha-type CGRP, CALC1, CGRP-I, Calcitonin gene-related peptide I

Gene ID: 24241

NCBI Accession: NP_001029127

UniProt: P01256

Pathways: Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour