CD41, CD61 antibody (Biotin)

Catalog No. ABIN111385

Product Details anti-CD41, CD61 Antibody (Biotin)

Target: CD41, CD61 (CD41,CD61)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD41, CD61 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Purification: Protein G chromatography.

Clone: M148

Isotype: IgG1

Application Details

Application Notes: Suitable for use in Flow Cytometric applications: 1 g to stain 1.0 x 10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL (OD280 nm)

Buffer: 0.01 M PBS, pH 7.2, containing 2.0 mM EDTA and 1.0 % BSA as buffer and 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CD41, CD61

Target: CD41, CD61 (CD41,CD61)

Abstract: CD41, CD61 Products

Background: Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.Synonyms: CD41, CD61, GP2B, GP3A, GPIIb, GPIIb-IIIa, GPalpha IIb, ITGA2B, ITGAB, ITGB3, Integrin alpha-IIb, Integrin beta-3, Platelet membrane glycoprotein IIb