KLKB1 antibody

Catalog No. ABIN111208

Product Details anti-KLKB1 Antibody

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KLKB1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)

Specificity: Recognizes two variants of Prekallikrein and its activation products Kallikrein (88 kDa and 85 kDa), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and Antithrombin III, and 45 kDa prekallikrein/kallikrein fragment(s). Recognizes Prekallikrein and its activation products in Human, Chimpanzee, Rhesus, and Baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in Human and Rhesus plasmas by approximately 60-80 % and 55 %, respectively. Does not cross-react with tissue Kallikrein

Purification: Protein G chromatography.

Immunogen: Purified Human prekallikrein.

Clone: 901

Isotype: IgG1

Application Details

Application Notes: Suitable for use in ELISA and Western blot. Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasmasamples.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.6 mg/mL (OD280 nm)

Buffer: PBS, pH 7.4 without preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KLKB1

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Abstract: KLKB1 Products

Synonyms: KLK3 antibody, PPK antibody, APS antibody, Kal-3 antibody, Kal3 antibody, Klk3 antibody, PSA antibody, KALP15 antibody, Kalp1 antibody, KLKB1 antibody, DKFZp459J2015 antibody, klkb1 antibody, kallikrein B1 antibody, kallikrein B, plasma 1 antibody, plasma kallikrein antibody, Plasma kallikrein antibody, kallikrein B, plasma (Fletcher factor) 1 antibody, coagulation factor XI antibody, kallikrein B1 L homeolog antibody, KLKB1 antibody, Klkb1 antibody, CpipJ_CPIJ004042 antibody, CpipJ_CPIJ014955 antibody, CpipJ_CPIJ020108 antibody, VAA_02266 antibody, LOC100549617 antibody, klkb1 antibody, klkb1.L antibody

Background: Plasma Kallikrein 1B is a serine proteinase of the S1 family It is secreted by the liver, kidney, adrenal gland and placenta. The zymogen is referred to as prekallikrein (PK) and is activated by Factor XIIa to an active two chain form, plasma kallikrein. In Fletcher syndrome plasma kallikrein is deficient, resulting in a prolonged partial thromboplastin time (PT).Synonyms: Fletcher factor, Plasma kallikrein

Gene ID: 3818

NCBI Accession: NP_000883

UniProt: P03952

Pathways: Complement System, Brown Fat Cell Differentiation