RECK antibody (AA 621-832)

Catalog No. ABIN1108847

Product Details anti-RECK Antibody

Target: RECK (Reversion-Inducing-Cysteine-Rich Protein with Kazal Motifs (RECK))

Binding Specificity: AA 621-832

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RECK antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts with RECK.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Immunogen: Recombinant RECK protein (621-832 a.a)

Clone: 32C10A

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for RECK

Target: RECK (Reversion-Inducing-Cysteine-Rich Protein with Kazal Motifs (RECK))

Alternative Name: RECK / ST15 (RECK Products)

Synonyms: ST15 antibody, St15 antibody, mRECK antibody, reversion inducing cysteine rich protein with kazal motifs antibody, reversion-inducing-cysteine-rich protein with kazal motifs antibody, RECK antibody, Reck antibody

Background: A membrane-anchored glycoprotein, RECK is encoded by a RECK gene (reversion-inducing cysteine-rich protein with Kazal motifs) identified as a transformation suppressor gene. This 110 kDa protein consists of 971a.a. The protein contains protease inhibitor like domains such as the Kazal motif, and epidermal growth factor (EGF) like repeats. Takahashi et al. reported that restoration pf RECK expression in malignant cells resulted in suppression of invasive activity with a concomitant decrease in the secretion of matrix metalloproteinase-9 (MMP-9), a key enzyme involved in tumor invasion and metastasis.Synonyms: Reversion-inducing cysteine-rich protein with Kazal motifs, Suppressor of tumorigenicity 15 protein

Gene ID: 8434

NCBI Accession: NP_066934

UniProt: O95980