FAS antibody

Catalog No. ABIN1106613

Product Details anti-FAS Antibody

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FAS antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Neutralization (Neut)

Specificity: This antibody reacts with Fas.

No Cross-Reactivity: Mouse (Murine)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Protein A agarose

Immunogen: Recombinant human Fas

Clone: ZB4

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2

Preservative: Azide free

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Alternative Name: CD95 / FAS (FAS Products)

Background: It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas (also known as CD95/APO-1) is a cell surface protein belonging to the tumor necrosis factor receptor superfamily, which is expressed in a variety of normal and neoplastic cells. Binding of FasL to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies results in rapid induction of apoptosis in Fas expressing cells. Clone ZB4 is known as Fas blocking, Fas neutralizing or Fas antagonistic antibody, whereas anti-human Fas antibody (clone CH-11) is known as the agonistic antibody.Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6

Gene ID: 355

NCBI Accession: NP_000034

UniProt: P25445

Pathways: p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity