TSH receptor antibody (Extracellular Domain)

Catalog No. ABIN1104855

Product Details anti-TSH receptor Antibody

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Binding Specificity: AA 101-115, Extracellular Domain

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This TSH receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Human TSH Receptor. This antibody is expected to recognize reported isoform 1 (NP_000360.2) and isoform 2 (NP_001018046.1). The immunizing peptide sequence corresponds to a part of the extracellular domain.

Predicted Reactivity: Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon (100%) Monkey, Marmoset, Sheep, Bovine (93%) Galago, Mouse, Rat, Elephant, Panda, Bat, Dog, Feline, Horse, Rabbit, Porcine, Opossum, Guinea pig, Turkey, Zebra finch, Chicken (87%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide C-SKVTHIEIRNTRNLT from an internal region of human TSH Receptor (NP_000360.2, NP_001018046.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon (100%), Monkey, Marmoset, Sheep, Bovine (93%), Galago, Mouse, Rat, Elephant, Panda, Bat, Dog, Feline, Horse, Rabbit, Porcine, Opossum, Guinea pig, Turkey, Zebra finch, Chicken (87%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: Peptide-ELISA (1:16000), WB (0.5 - 2 μg/mL)

Usage: Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Approx 28kD band observed in Human Thyroid Gland lysates (calculated MW of 28.4kD according to NP_001018046.1). Recommended concentration: 0.5-2 μg/mL.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Tris-buffered saline,  pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Minimize freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for TSH receptor

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Alternative Name: TSH Receptor / TSHR (TSHR Products)

Synonyms: CHNG1 antibody, LGR3 antibody, hTSHR-I antibody, AI481368 antibody, hypothroid antibody, hyt antibody, pet antibody, TSHRA antibody, TSH-R antibody, thyroid stimulating hormone receptor antibody, tshr antibody, TSHR antibody, Tshr antibody

Background: Name/Gene ID: TSHR
Subfamily: Glycoprotein hormone
Family: GPCR

Synonyms: TSHR, CHNG1, HTSHR-I, LGR3, Thyrotrophin receptor, TSH-R, TSH receptor, Thyrotropin receptor

Gene ID: 7253

NCBI Accession: NP_000360, NP_001018046

UniProt: P16473

Pathways: Thyroid Hormone Synthesis