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PPP1R13L antibody (AA 775-800)

Rockland 600-401-926s PPP1R13L Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Rockland
Catalog No. ABIN1043889
Supplier Product No.: 600-401-926s
  • Target See all PPP1R13L Antibodies
    PPP1R13L (Protein Phosphatase 1, Regulatory Subunit 13 Like (PPP1R13L))
    Binding Specificity
    • 16
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 775-800
    Reactivity
    • 54
    • 21
    • 18
    • 7
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 49
    • 5
    Rabbit
    Clonality
    • 52
    • 2
    Polyclonal
    Conjugate
    • 29
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPP1R13L antibody is un-conjugated
    Application
    • 43
    • 15
    • 14
    • 14
    • 13
    • 10
    • 10
    • 9
    • 3
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Supplier Product No.
    600-401-926s
    Supplier
    Rockland
    Purpose
    iASSP Antibody
    Cross-Reactivity (Details)
    This affinity-purified antibody is directed against the human iASPP protein.
    Characteristics
    Synonyms: rabbit anti-iASPP antibody, inhibitor of apoptosis stimulating protein of p53 antibody, Inhibitor of ASPP protein antibody, RelA-associated inhibitor, NFkB interacting protein 1 antibody, Protein iASPP, NKIP1 antibody, PPP1R13B-like protein antibody, IASPP, NKIP1, PPP1R13BL, RAI, PPP1R13L
    Purification
    The product was affinity purified from monospecific antiserum by immunoaffinity purification.
    Sterility
    Sterile filtered
    Immunogen

    Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 775-800 of human iASPP (isoform 1) protein.

    Immunogen Type: Conjugated Peptide

    Isotype
    IgG
    Top Product
    Discover our top product PPP1R13L Primary Antibody
  • Application Notes

    Immunohistochemistry Dilution: 1:1,000 - 1:5,000

    Application Note: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry and by western blot.  Specific conditions for reactivity should be optimized by the end user.  Expect bands approximately 100 kDa and 50 kDa in size corresponding to isoforms 1 and 2 respectively of iASPP protein by western blotting in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:1,000 - 1:5,000

    ELISA Dilution: 1:40,000 - 1:160,000

    Other: User Optimized

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Expiry Date
    12 months
  • Liu, Lu, Zhong: "ASPP--Apoptotic specific regulator of p53." in: Biochimica et biophysica acta, Vol. 1756, Issue 1, pp. 77-80, (2005) (PubMed).

  • Target
    PPP1R13L (Protein Phosphatase 1, Regulatory Subunit 13 Like (PPP1R13L))
    Alternative Name
    PPP1R13L (PPP1R13L Products)
    Background
    Background: ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53.  iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1.
    Gene ID
    10848, 63003907
    UniProt
    Q8WUF5
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