PPP2CA antibody (Isoform alpha)

Catalog No. ABIN1042658

Product Details anti-PPP2CA Antibody

Target: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Binding Specificity: Isoform alpha

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This PPP2CA antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificity: Rcognizes very well isoforms alpha and rat delta, weakly the human beta isoform, very weakly the rabbit gamma isoform

Cross-Reactivity: Chicken, Pig, Rabbit, Xenopus laevis

Cross-Reactivity (Details): Human, Mouse, Rat. Predicted to react with Porcine, Rabbit, Chicken, Xenopus

Purification: Protein G

Immunogen: Peptide from rat PP2A isoform alpha (Immunogen sequence: 398-CASGKRKKDEISVD-411)

Clone: 2G9

Isotype: IgG1

Application Details

Application Notes: Optimal antibody dilution should be determined by titration, however as a guideline try up to 1:1,000 for western blot

Comment:

Myeloma, fusion partners: X63-Ag8.653

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Purified antibody (from supernatant) containing PBS + 0.1 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

References for anti-PPP2CA antibody (ABIN1042658)

Sontag, Nunbhakdi-Craig, Sontag, Diaz-Arrastia, Ogris, Dayal, Lentz, Arning, Bottiglieri: "Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 11, pp. 2751-9, (2007) (PubMed).

Sontag, Hladik, Montgomery, Luangpirom, Mudrak, Ogris, White: "Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 10, pp. 1080-91, (2004) (PubMed).

Target Details for PPP2CA

Target: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Alternative Name: PP2A alpha (PPP2CA Products)

Background: Synonyms:
B/PR55, B/PR55 alpha, PP2A alpha antibody,PP2A C antibody,PP2A-alpha antibody,PP2AA_HUMAN antibody,PP2Ac antibody,PP2CA antibody

Gene ID: 5515, 19052, 24672

OMIM: 176915

UniProt: P67775, P63330, P63331

Pathways: PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Hepatitis C, Toll-Like Receptors Cascades