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News

New possibilities for manipulating Notch signalling

The Notch pathway is responsible for the correct development of many tissues and cell types. Recent findings link mutations and/or abnormal signalling of Notch receptors with the onset of human diseases. Therefore, the Notch pathway is a promising therapeutic target. Unfortunately, until recently, there have been no specific inhibitors and/or agonists for human Notch receptors (NOTCH1-4), leaving the potential unexplored.  » Read more
17.07.2008  |  Anna Lena Marwedel      RSS Feed  Research News

New supplier: Biovision

Biovision antibodies are now listed at antibodies-online.com. »Show Biovision antibodies
17.07.2008  |  Tim Hiddemann      RSS Feed  New Antibodies

New supplier: Lifespan antibodies at antibodies-online.com

More than 34.000 Lifespan antibodies are now available at antibodies-online.com. »Show Lifespan-antibodies
17.07.2008  |  Tim Hiddemann      RSS Feed  New Antibodies

Nutritional Control of Reproductive Status in Honeybees via DNA Methylation

Areas: DNA
Silencing the expression of DNA methyltransferase Dnmt3 in newly hatched Apis larvae leads to a royal jelly-like effect on larva development. According to scientists from the Australian National University, the majority of larvae treated with Dnmt3 siRNA grew up to be queens with fully developed ovaries.  » Read more
01.07.2008  |  Anna Lena Marwedel      RSS Feed  Research News

Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

A recent study revealed that Listeria monocytogenes can replicate in the vacuoles within macrophages. Cheryl L. Birmingham and her team from the University of Toronto in Canada observed the localisation of bacteria in large LAMP1+ compartments that they denoted spacious Listeria-containing phagosomes (SLAPs). The SLAPs could also be seen in vitro. They turned out to be non-acidic and non-degradative compartments that are generated in an autophagy-dependent manner.  » Read more
01.07.2008  |  Anna Lena Marwedel      RSS Feed  Research News


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